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Science 1 December 2000:
Vol. 290. no. 5497, pp. 1775 - 1779
DOI: 10.1126/science.290.5497.1775
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Reports

From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice

Timothy R. Brazelton, Fabio M. V. Rossi, Gilmor I. Keshet, Helen M. Blau*

After intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes) developed in the central nervous system. Flow cytometry revealed a population of donor-derived cells in the brain with characteristics distinct from bone marrow. Confocal microscopy of individual cells showed that hundreds of marrow-derived cells in brain sections expressed gene products typical of neurons (NeuN, 200-kilodalton neurofilament, and class III beta -tubulin) and were able to activate the transcription factor cAMP response element-binding protein (CREB). The generation of neuronal phenotypes in the adult brain 1 to 6 months after an adult bone marrow transplant demonstrates a remarkable plasticity of adult tissues with potential clinical applications.

Department of Molecular Pharmacology, CCSR 4215, 269 Campus Drive, Stanford University, Stanford, CA 94305-5175, USA.
*   To whom correspondence should be addressed. E-mail: hblau{at}stanford.edu

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Mesenchymal Stem Cells Acquire Characteristics of Cells in the Periodontal Ligament in vitro.
P.R. Kramer, S. Nares, S.F. Kramer, D. Grogan, and M. Kaiser (2004)
Journal of Dental Research 83, 27-34
   Abstract »    Full Text »    PDF »
Stem Cells: Review and Update.
K. G. Sylvester and M. T. Longaker (2004)
Arch Surg 139, 93-99
   Abstract »    Full Text »    PDF »
Limited Contribution of Circulating Cells to the Development and Maintenance of Nonhematopoietic Bovine Tissues.
M. Niku, L. Ilmonen, T. Pessa-Morikawa, and A. Iivanainen (2004)
Stem Cells 22, 12-20
   Abstract »    Full Text »    PDF »
Choroidal Neovascularization Is Provided by Bone Marrow Cells.
M. Tomita, H. Yamada, Y. Adachi, Y. Cui, E. Yamada, A. Higuchi, K. Minamino, Y. Suzuki, M. Matsumura, and S. Ikehara (2004)
Stem Cells 22, 21-26
   Abstract »    Full Text »    PDF »
Cellular and Genetic Characterization of Human Adult Bone Marrow-Derived Neural Stem-Like Cells: A Potential Antiglioma Cellular Vector.
J. Lee, A. G. Elkahloun, S. A. Messina, N. Ferrari, D. Xi, C. L. Smith, R. Cooper Jr., P. S. Albert, and H. A. Fine (2003)
Cancer Res. 63, 8877-8889
   Abstract »    Full Text »    PDF »
Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model.
F. Norol, P. Merlet, R. Isnard, P. Sebillon, N. Bonnet, C. Cailliot, C. Carrion, M. Ribeiro, F. Charlotte, P. Pradeau, et al. (2003)
Blood 102, 4361-4368
   Abstract »    Full Text »    PDF »
Hematopoietic progenitors express neural genes.
J. Goolsby, M. C. Marty, D. Heletz, J. Chiappelli, G. Tashko, D. Yarnell, P. S. Fishman, S. Dhib-Jalbut, C. T. Bever Jr., B. Pessac, et al. (2003)
PNAS 100, 14926-14931
   Abstract »    Full Text »    PDF »
Class III {beta}-Tubulin Isotype: A Key Cytoskeletal Protein at the Crossroads of Developmental Neurobiology and Tumor Neuropathology.
C. D. Katsetos, A. Legido, E. Perentes, and S. J. Mork (2003)
J Child Neurol 18, 851-866
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Primordial Hematopoietic Stem Cells Generate Microglia But Not Myelin-Forming Cells in a Neural Environment.
S. Vitry, J. Y. Bertrand, A. Cumano, and M. Dubois-Dalcq (2003)
J. Neurosci. 23, 10724-10731
   Abstract »    Full Text »    PDF »
Plasticity of marrow-derived stem cells.
E. L. Herzog, L. Chai, and D. S. Krause (2003)
Blood 102, 3483-3493
   Abstract »    Full Text »    PDF »


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