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Science 6 October 2000:
Vol. 290. no. 5489, pp. 84 - 89
DOI: 10.1126/science.290.5489.84
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Immune Inhibitory Receptors

Jeffrey V. Ravetch,1 Lewis L. Lanier2

With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the pairing of activation and inhibition is necessary to initiate, amplify, and then terminate immune responses. In some cases, the activating and inhibitory receptors recognize similar ligands, and the net outcome is determined by the relative strength of these opposing signals. The importance of this modulation is demonstrated by the sometimes fatal autoimmune disorders observed in mice with targeted disruption of inhibitory receptors. The significance of these receptors is further evidenced by the conservation of immunoreceptor tyrosine-based inhibitory motifs during their evolution.

1 Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10021, USA.
2 Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA.

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Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors.
Y. Kaneko, F. Nimmerjahn, M. P. Madaio, and J. V. Ravetch (2006)
J. Exp. Med. 203, 789-797
   Abstract »    Full Text »    PDF »
Recombinant Ig-Like Transcript 3-Fc Modulates T Cell Responses via Induction of Th Anergy and Differentiation of CD8+ T Suppressor Cells..
S. Kim-Schulze, L. Scotto, G. Vlad, F. Piazza, H. Lin, Z. Liu, R. Cortesini, and N. Suciu-Foca (2006)
J. Immunol. 176, 2790-2798
   Abstract »    Full Text »    PDF »
NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors.
Z. Fan, P. Yu, Y. Wang, Y. Wang, M. L. Fu, W. Liu, Y. Sun, and Y.-X. Fu (2006)
Blood 107, 1342-1351
   Abstract »    Full Text »    PDF »
Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation.
S. Zhang and J. H. Phillips (2006)
J. Leukoc. Biol. 79, 363-368
   Abstract »    Full Text »    PDF »
Inhibition of Immune Responses by ITAM-Bearing Receptors.
J. A. Hamerman and L. L. Lanier (2006)
Sci. STKE 2006, re1
   Abstract »    Full Text »    PDF »
Cytokine-regulated expression and inhibitory function of Fc{gamma}RIIB1 and -B2 receptors in human dendritic cells.
N. Guriec, C. Daniel, K. Le Ster, E. Hardy, and C. Berthou (2006)
J. Leukoc. Biol. 79, 59-70
   Abstract »    Full Text »    PDF »
Siglecs--the major subfamily of I-type lectins.
A. Varki and T. Angata (2006)
Glycobiology 16, 1R-27R
   Abstract »    Full Text »    PDF »
Regulation of Myeloid Cell Function through the CD200 Receptor.
M. C. Jenmalm, H. Cherwinski, E. P. Bowman, J. H. Phillips, and J. D. Sedgwick (2006)
J. Immunol. 176, 191-199
   Abstract »    Full Text »    PDF »
The Inhibitory Receptor IRp60 (CD300a) Is Expressed and Functional on Human Mast Cells.
I. Bachelet, A. Munitz, A. Moretta, L. Moretta, and F. Levi-Schaffer (2005)
J. Immunol. 175, 7989-7995
   Abstract »    Full Text »    PDF »
Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding.
F. Nimmerjahn and J. V. Ravetch (2005)
Science 310, 1510-1512
   Abstract »    Full Text »    PDF »
Human Cytomegalovirus Encodes an MHC Class I-Like Molecule (UL142) That Functions to Inhibit NK Cell Lysis.
M. R. Wills, O. Ashiru, M. B. Reeves, G. Okecha, J. Trowsdale, P. Tomasec, G. W. G. Wilkinson, J. Sinclair, and J. G. P. Sissons (2005)
J. Immunol. 175, 7457-7465
   Abstract »    Full Text »    PDF »
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3.
G. Penna, A. Roncari, S. Amuchastegui, K. C. Daniel, E. Berti, M. Colonna, and L. Adorini (2005)
Blood 106, 3490-3497
   Abstract »    Full Text »    PDF »
Fc{gamma}RIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.
H. Kono, C. Kyogoku, T. Suzuki, N. Tsuchiya, H. Honda, K. Yamamoto, K. Tokunaga, and Z.-I. Honda (2005)
Hum. Mol. Genet. 14, 2881-2892
   Abstract »    Full Text »    PDF »
Down-Regulation of Basophil Function by Human CD200 and Human Herpesvirus-8 CD200.
I. Shiratori, M. Yamaguchi, M. Suzukawa, K. Yamamoto, L. L. Lanier, T. Saito, and H. Arase (2005)
J. Immunol. 175, 4441-4449
   Abstract »    Full Text »    PDF »
Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment.
A. Kumanogoh, T. Shikina, C. Watanabe, N. Takegahara, K. Suzuki, M. Yamamoto, H. Takamatsu, D. V. R. Prasad, M. Mizui, T. Toyofuku, et al. (2005)
Int. Immunol. 17, 1277-1282
   Abstract »    Full Text »    PDF »
NK Cells Play a Critical Role in the Regulation of Class I-Deficient Hemopoietic Stem Cell Engraftment: Evidence for NK Tolerance Correlates with Receptor Editing.
Y. Huang, F. Rezzoug, H. Xu, P. M. Chilton, C. L. Schanie, I. Fugier-Vivier, and S. T. Ildstad (2005)
J. Immunol. 175, 3753-3761
   Abstract »    Full Text »    PDF »


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