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Science 25 February 2000:
Vol. 287. no. 5457, pp. 1427 - 1430
DOI: 10.1126/science.287.5457.1427
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Review

Out of Eden: Stem Cells and Their Niches

Fiona M. Watt, 1 and Brigid L. M. Hogan 2

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.

1 Keratinocyte Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
2 Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Centre, Nashville, TN 37232-2175, USA.

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