Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 22 January 1999:
Vol. 283. no. 5401, pp. 534 - 537
DOI: 10.1126/science.283.5401.534

Reports

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

Christopher R. R. Bjornson, *dagger ddagger Rodney L. Rietze, *§ Brent A. Reynolds, M. Cristina Magli, Angelo L. Vescovi ddagger

Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.

C. R. R. Bjornson, R. L. Rietze, B. A. Reynolds, NeuroSpheres Limited, 3330 Hospital Drive Northwest, Calgary, AB, Canada T2N 4N1. M. C. Magli, Istituto di Mutagenesi, Consiglio Nazionale Recerche, Via Svezia 2/A, Pisa, Italy I-56124. A. L. Vescovi, Neurospheres Limited, 3330 Hospital Drive Northwest, Calgary, AB, Canada T2N 4N1, and Istituto Nazionale Neurologico C. Besta, Via Celoria 11, Milan, Italy I-20133.
*   These authors contributed equally to this work.

dagger    Present address: University of Washington, Department of Biochemistry, Seattle, WA 98195-7350, USA.

ddagger    To whom correspondence should be addressed at University of Washington, Department of Biochemistry, Seattle, WA 98195-7350, USA, e-mail: adanac{at}u.washington.edu (for C.R.R.B.) and at Istituto Nazionale Neurologico C. Besta, Via Celoria 11, Milan, Italy I-20133, e-mail: vescovi{at}istituto-besta.it (for A.L.V.).

§   Present address: Walter Eliza Hall Institute, Medical Research, Parkville, Victoria, Australia 3050. 


Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Concurrent Vasculogenesis and Neurogenesis From Adult Neural Stem Cells.
M. Ii, H. Nishimura, H. Sekiguchi, N. Kamei, A. Yokoyama, M. Horii, and T. Asahara (2009)
Circ. Res. 105, 860-868
   Abstract »    Full Text »    PDF »
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants.
X. Lu and Y. Kang (2009)
PNAS 106, 9385-9390
   Abstract »    Full Text »    PDF »
Tracheal Replacement With Cryopreserved, Decellularized, or Glutaraldehyde-Treated Aortic Allografts..
A. Seguin, D. Radu, M. Holder-Espinasse, P. Bruneval, A. Fialaire-Legendre, M. Duterque-Coquillaud, A. Carpentier, and E. Martinod (2009)
Ann. Thorac. Surg. 87, 861-867
   Abstract »    Full Text »    PDF »
Reviews: Stem Cells and Female Reproduction.
Hongling Du and H. S. Taylor (2009)
Reproductive Sciences 16, 126-139
   Abstract »    PDF »
Microenvironment drives the endothelial or neural fate of differentiating embryonic stem cells coexpressing neuropilin-1 and Flk-1.
A. Gualandris, A. Noghero, M. Geuna, M. Arese, D. Valdembri, G. Serini, and F. Bussolino (2009)
FASEB J 23, 68-78
   Abstract »    Full Text »    PDF »
Stem cell myths.
T. Magnus, Y. Liu, G. C Parker, and M. S Rao (2008)
Phil Trans R Soc B 363, 9-22
   Abstract »    Full Text »    PDF »
Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential.
K. J.L Fernandes, J. G Toma, and F. D Miller (2008)
Phil Trans R Soc B 363, 185-198
   Abstract »    Full Text »    PDF »
Case 126: Extramedullary Hematopoiesis.
Y. M. Berkmen and B. A. Zalta (2007)
Radiology 245, 905-908
   Full Text »    PDF »
Endogenous Bone Marrow Derived Cells Express Retinal Pigment Epithelium Cell Markers and Migrate to Focal Areas of RPE Damage.
Y. Li, P. Atmaca-Sonmez, C. L. Schanie, S. T. Ildstad, H. J. Kaplan, and V. Enzmann (2007)
Invest. Ophthalmol. Vis. Sci. 48, 4321-4327
   Abstract »    Full Text »    PDF »
Adhesion Is Prerequisite, But Alone Insufficient, to Elicit Stem Cell Pluripotency.
P. Karpowicz, T. Inoue, S. Runciman, B. Deveale, R. Seaberg, M. Gertsenstein, L. Byers, Y. Yamanaka, S. Tondat, J. Slevin, et al. (2007)
J. Neurosci. 27, 5437-5447
   Abstract »    Full Text »    PDF »
Foetal fibroblasts introduced to cleaving mouse embryos contribute to full-term development.
A. Piliszek, J. A Modlinski, K. Pysniak, and J. Karasiewicz (2007)
Reproduction 133, 207-218
   Abstract »    Full Text »    PDF »
Primary Glioblastomas Express Mesenchymal Stem-Like Properties.
C.-L. Tso, P. Shintaku, J. Chen, Q. Liu, J. Liu, Z. Chen, K. Yoshimoto, P. S. Mischel, T. F. Cloughesy, L. M. Liau, et al. (2006)
Mol. Cancer Res. 4, 607-619
   Abstract »    Full Text »    PDF »
Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism.
A. Nakao, H. Toyokawa, K. Kimizuka, M. A. Nalesnik, I. Nozaki, R. J. Bailey, A. J. Demetris, T. E. Starzl, and N. Murase (2006)
Blood 108, 1413-1420
   Abstract »    Full Text »    PDF »
Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival..
T. Wada, J. J. Haigh, M. Ema, S. Hitoshi, R. Chaddah, J. Rossant, A. Nagy, and D. van der Kooy (2006)
J. Neurosci. 26, 6803-6812
   Abstract »    Full Text »    PDF »
Neurotrophic Enhancers as Therapy for Behavioral Deficits in Rodent Models of Huntington's Disease: Use of Gangliosides, Substituted Pyrimidines, and Mesenchymal Stem Cells..
G. L. Dunbar, M. I. Sandstrom, J. Rossignol, and L. Lescaudron (2006)
Behav Cogn Neurosci Rev 5, 63-79
   Abstract »    PDF »
Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles.
H. Yu, D. Fang, S. M. Kumar, L. Li, T. K. Nguyen, G. Acs, M. Herlyn, and X. Xu (2006)
Am. J. Pathol. 168, 1879-1888
   Abstract »    Full Text »    PDF »
Regeneration Gaps: Observations on Stem Cells and Cardiac Repair.
C. E. Murry, H. Reinecke, and L. M. Pabon (2006)
J. Am. Coll. Cardiol. 47, 1777-1785
   Abstract »    Full Text »    PDF »
Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic {beta}-Cell Fate.
J. Taneera, A. Rosengren, E. Renstrom, J. M. Nygren, P. Serup, P. Rorsman, and S. E. W. Jacobsen (2006)
Diabetes 55, 290-296
   Abstract »    Full Text »    PDF »
Isolation of "Side Population" Progenitor Cells From Healthy Arteries of Adult Mice.
J. Sainz, A. Al Haj Zen, G. Caligiuri, C. Demerens, D. Urbain, M. Lemitre, and A. Lafont (2006)
Arterioscler Thromb Vasc Biol 26, 281-286
   Abstract »    Full Text »    PDF »
Cell-Based Cardiac Repair: Reflections at the 10-Year Point.
C. E. Murry, L. J. Field, and P. Menasche (2005)
Circulation 112, 3174-3183
   Full Text »    PDF »
Activation of Myogenic Differentiation Pathways in Adult Bone Marrow-Derived Stem Cells.
F. Belema Bedada, A. Technau, H. Ebelt, M. Schulze, and T. Braun (2005)
Mol. Cell. Biol. 25, 9509-9519
   Abstract »    Full Text »    PDF »
Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions?.
V. Kindler (2005)
J. Leukoc. Biol. 78, 836-844
   Abstract »    Full Text »    PDF »
A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis.
M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia (2005)
J. Cell Sci. 118, 4343-4352
   Abstract »    Full Text »    PDF »
Stem Cell Research: Paths to Cancer Therapies and Regenerative Medicine.
I. Weissman (2005)
JAMA 294, 1359-1366
   Abstract »    Full Text »    PDF »
Embryonic stem cells and tissue engineering: delivering stem cells to the clinic.
A Vats, N S Tolley, A E Bishop, and J M Polak (2005)
J R Soc Med 98, 346-350
   Full Text »    PDF »
History and perspectives of pituitary folliculo-stellate cell research.
W. Allaerts and H. Vankelecom (2005)
Eur. J. Endocrinol. 153, 1-12
   Abstract »    Full Text »    PDF »
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy.
A. M. Wobus and K. R. Boheler (2005)
Physiol Rev 85, 635-678
   Abstract »    Full Text »    PDF »
Pituitary Transcription Factor-1 Induces Transient Differentiation of Adult Hepatic Stem Cells into Prolactin-Producing Cells in Vivo.
E. J. Lee, T. Russell, L. Hurley, and J. L. Jameson (2005)
Mol. Endocrinol. 19, 964-971
   Abstract »    Full Text »    PDF »
Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals.
D. J. Pearton, Y. Yang, and D. Dhouailly (2005)
PNAS 102, 3714-3719
   Abstract »    Full Text »    PDF »
Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells.
A. Hermann, R. Gastl, S. Liebau, M. O. Popa, J. Fiedler, B. O. Boehm, M. Maisel, H. Lerche, J. Schwarz, R. Brenner, et al. (2004)
J. Cell Sci. 117, 4411-4422
   Abstract »    Full Text »    PDF »
Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses.
H. Shankar, S. Murugappan, S. Kim, J. Jin, Z. Ding, K. Wickman, and S. P. Kunapuli (2004)
Blood 104, 1335-1343
   Abstract »    Full Text »    PDF »
Adult Bone Marrow Stromal Cells in the Embryonic Brain: Engraftment, Migration, Differentiation, and Long-Term Survival.
G. Munoz-Elias, A. J. Marcus, T. M. Coyne, D. Woodbury, and I. B. Black (2004)
J. Neurosci. 24, 4585-4595
   Abstract »    Full Text »    PDF »
Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm.
G. Prindull and D. Zipori (2004)
Blood 103, 2892-2899
   Abstract »    Full Text »    PDF »
Regenerative Response in Ischemic Brain Restricted by p21cip1/waf1.
J. Qiu, Y. Takagi, J. Harada, N. Rodrigues, M. A. Moskowitz, D. T. Scadden, and T. Cheng (2004)
J. Exp. Med. 199, 937-945
   Abstract »    Full Text »    PDF »
Lung Cells Transplanted to Irradiated Recipients Generate Lymphohematopoietic Progeny.
S. Abe, G. Lauby, C. Boyer, L. Manouilova, S. I. Rennard, and J. G. Sharp (2004)
Am. J. Respir. Cell Mol. Biol. 30, 491-499
   Abstract »    Full Text »    PDF »
Human Mesenchymal Stem Cells Form Purkinje Fibers in Fetal Sheep Heart.
J. A. Airey, G. Almeida-Porada, E. J. Colletti, C. D. Porada, J. Chamberlain, M. Movsesian, J. L. Sutko, and E. D. Zanjani (2004)
Circulation 109, 1401-1407
   Abstract »    Full Text »    PDF »
Human Pancreatic Islet-Derived Progenitor Cell Engraftment in Immunocompetent Mice.
E. J. Abraham, S. Kodama, J. C. Lin, M. Ubeda, D. L. Faustman, and J. F. Habener (2004)
Am. J. Pathol. 164, 817-830
   Abstract »    Full Text »    PDF »
Some Like It Plastic.
A. Leri, J. Kajstura, B. Nadal-Ginard, and P. Anversa (2004)
Circ. Res. 94, 132-134
   Full Text »    PDF »
Recipes for adult stem cell plasticity: fusion cuisine or readymade?.
M R Alison, R Poulsom, W R Otto, P Vig, M Brittan, N C Direkze, M Lovell, T C Fang, S L Preston, and N A Wright (2004)
J. Clin. Pathol. 57, 113-120
   Abstract »    Full Text »    PDF »
Enhanced Induction of RPE Lineage Markers in Pluripotent Neural Stem Cells Engrafted into the Adult Rat Subretinal Space.
V. Enzmann, R. M. Howard, Y. Yamauchi, S. R. Whittemore, and H. J. Kaplan (2003)
Invest. Ophthalmol. Vis. Sci. 44, 5417-5422
   Abstract »    Full Text »    PDF »
Primordial Hematopoietic Stem Cells Generate Microglia But Not Myelin-Forming Cells in a Neural Environment.
S. Vitry, J. Y. Bertrand, A. Cumano, and M. Dubois-Dalcq (2003)
J. Neurosci. 23, 10724-10731
   Abstract »    Full Text »    PDF »
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice.
S. Kodama, W. Kuhtreiber, S. Fujimura, E. A. Dale, and D. L. Faustman (2003)
Science 302, 1223-1227
   Abstract »    Full Text »    PDF »
Nonhepatosplenic Extramedullary Hematopoiesis: Associated Diseases, Pathology, Clinical Course, and Treatment.
C. A. Koch, C.-Y. Li, R. A. Mesa, and A. Tefferi (2003)
Mayo Clin. Proc. 78, 1223-1233
   Abstract »    PDF »
Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis.
J. Imitola, E. Y. Snyder, and S. J. Khoury (2003)
Physiol Genomics 14, 171-197
   Abstract »    Full Text »    PDF »
Skeletal muscle engraftment potential of adult mouse skin side population cells.
F. Montanaro, K. Liadaki, J. Volinski, A. Flint, and L. M. Kunkel (2003)
PNAS 100, 9336-9341
   Abstract »    Full Text »    PDF »
Stem Cell Research: Elephants in the Room.
N. D. Theise (2003)
Mayo Clin. Proc. 78, 1004-1009
   PDF »
Prometheus's Vulture and the Stem-Cell Promise.
N. Rosenthal (2003)
N. Engl. J. Med. 349, 267-274
   Full Text »    PDF »
BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.
P. Rajan, D. M. Panchision, L. F. Newell, and R. D.G. McKay (2003)
J. Cell Biol. 161, 911-921
   Abstract »    Full Text »    PDF »
Stem cells in the skin: waste not, Wnt not.
L. Alonso and E. Fuchs (2003)
Genes & Dev. 17, 1189-1200
   Full Text »    PDF »
SHED: Stem cells from human exfoliated deciduous teeth.
M. Miura, S. Gronthos, M. Zhao, B. Lu, L. W. Fisher, P. G. Robey, and S. Shi (2003)
PNAS 100, 5807-5812
   Abstract »    Full Text »    PDF »
Hematopoietic stem cells: can old cells learn new tricks?.
A. D. Ho and M. Punzel (2003)
J. Leukoc. Biol. 73, 547-555
   Abstract »    Full Text »    PDF »
Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow.
S. Gronthos, A. C. W. Zannettino, S. J. Hay, S. Shi, S. E. Graves, A. Kortesidis, and P. J. Simmons (2003)
J. Cell Sci. 116, 1827-1835
   Abstract »    Full Text »    PDF »
Increased Chimerism of Bronchial and Alveolar Epithelium in Human Lung Allografts Undergoing Chronic Injury.
W. Kleeberger, A. Versmold, T. Rothamel, S. Glockner, M. Bredt, A. Haverich, U. Lehmann, and H. Kreipe (2003)
Am. J. Pathol. 162, 1487-1494
   Abstract »    Full Text »    PDF »
Spotlight on stem cells--makes old hearts fresh.
M. A.G. van der Heyden, J. Hescheler, and C. L. Mummery (2003)
Cardiovasc Res 58, 241-245
   Full Text »    PDF »
Origin and use of embryonic and adult stem cells in differentiation and tissue repair.
R. Passier and C. Mummery (2003)
Cardiovasc Res 58, 324-335
   Abstract »    Full Text »    PDF »
Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells.
D. P. Griese, S. Achatz, C. A. Batzlsperger, U. G. Strauch, B. Grumbeck, J. Weil, and G. A.J. Riegger (2003)
Cardiovasc Res 58, 469-477
   Abstract »    Full Text »    PDF »
Neural Stem Cells: An Overview.
R. Galli, A. Gritti, L. Bonfanti, and A. L. Vescovi (2003)
Circ. Res. 92, 598-608
   Abstract »    Full Text »    PDF »
Cellular origins of atherosclerosis: towards ontogenetic endgame?.
T. M. DOHERTY, P. K. SHAH, and T. B. RAJAVASHISTH (2003)
FASEB J 17, 592-597
   Full Text »    PDF »
Human embryonic stem cells: research, ethics and policy.
G. d. Wert and C. Mummery (2003)
Hum. Reprod. 18, 672-682
   Abstract »    Full Text »    PDF »
The new stem cell biology: something for everyone.
S L Preston, M R Alison, S J Forbes, N C Direkze, R Poulsom, and N A Wright (2003)
Mol. Pathol. 56, 86-96
   Abstract »    Full Text »    PDF »
Treatment of Chronic Wounds With Bone Marrow-Derived Cells.
E. V. Badiavas and V. Falanga (2003)
Arch Dermatol 139, 510-516
   Abstract »    Full Text »    PDF »
Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species.
M. Tummers and I. Thesleff (2003)
Development 130, 1049-1057
   Abstract »    Full Text »    PDF »
Generation of different fates from multipotent muscle stem cells.
M. R. Wada, M. Inagawa-Ogashiwa, S. Shimizu, S. Yasumoto, and N. Hashimoto (2003)
Development 129, 2987-2995
   Abstract »    Full Text »    PDF »
Erythropoietin receptor signalling is required for normal brain development.
X. Yu, J. J. Shacka, J. B. Eells, C. Suarez-Quian, R. M. Przygodzki, B. Beleslin-Cokic, C.-S. Lin, V. M. Nikodem, B. Hempstead, K. C. Flanders, et al. (2003)
Development 129, 505-516
   Abstract »    Full Text »    PDF »
Restoration of Spermatogenesis in Infertile Mice by Sertoli Cell Transplantation.
T. Shinohara, K. E. Orwig, M. R. Avarbock, and R. L. Brinster (2003)
Biol Reprod 68, 1064-1071
   Abstract »    Full Text »    PDF »
Plastic adult stem cells: will they graduate from the school of hard knocks?.
M. R. Alison, R. Poulsom, W. R. Otto, P. Vig, M. Brittan, N. C. Direkze, S. L. Preston, and N. A. Wright (2003)
J. Cell Sci. 116, 599-603
   Abstract »    Full Text »    PDF »
Realistic Prospects for Stem Cell Therapeutics.
G. Q. Daley, M. A. Goodell, and E. Y. Snyder (2003)
Hematology 2003, 398-418
   Abstract »    Full Text »    PDF »
Ectoderm to Mesoderm Lineage Switching During Axolotl Tail Regeneration.
K. Echeverri and E. M. Tanaka (2002)
Science 298, 1993-1996
   Abstract »    Full Text »    PDF »
Human Adipose Tissue Is a Source of Multipotent Stem Cells.
P. A. Zuk, M. Zhu, P. Ashjian, D. A. De Ugarte, J. I. Huang, H. Mizuno, Z. C. Alfonso, J. K. Fraser, P. Benhaim, and M. H. Hedrick (2002)
Mol. Biol. Cell 13, 4279-4295
   Abstract »    Full Text »    PDF »
Fetal Brain Progenitor Cells Transdifferentiate to Fates Outside the Nervous System.
H. S. U, W. Alilain, and F. Saljooque (2002)
Mol. Endocrinol. 16, 2645-2656
   Abstract »    Full Text »    PDF »
Emergence of muscle and neural hematopoiesis in humans.
K. E. Jay, L. Gallacher, and M. Bhatia (2002)
Blood 100, 3193-3202
   Abstract »    Full Text »    PDF »
Hair follicle dermal cells repopulate the mouse haematopoietic system.
M. Lako, L. Armstrong, P. M. Cairns, S. Harris, N. Hole, and C. A. B. Jahoda (2002)
J. Cell Sci. 115, 3967-3974
   Abstract »    Full Text »    PDF »
A molecular profile of a hematopoietic stem cell niche.
J. A. Hackney, P. Charbord, B. P. Brunk, C. J. Stoeckert, I. R. Lemischka, and K. A. Moore (2002)
PNAS 99, 13061-13066
   Abstract »    Full Text »    PDF »
The therapeutic potential of stem cells from adults.
I. Kuehnle and M. A Goodell (2002)
BMJ 325, 372-376
   Full Text »    PDF »
Variant Forms of alpha -Fetoprotein Transcripts Expressed in Human Hematopoietic Progenitors. IMPLICATIONS FOR THEIR DEVELOPMENTAL POTENTIAL TOWARDS ENDODERM.
H. Kubota, R. W. Storms, and L. M. Reid (2002)
J. Biol. Chem. 277, 27629-27635
   Abstract »    Full Text »    PDF »
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
L. Yang, S. Li, H. Hatch, K. Ahrens, J. G. Cornelius, B. E. Petersen, and A. B. Peck (2002)
PNAS 99, 8078-8083
   Abstract »    Full Text »    PDF »
Erythropoietin and VEGF Promote Neural Outgrowth from Retinal Explants in Postnatal Rats.
S. Bocker-Meffert, P. Rosenstiel, C. Rohl, N. Warneke, J. Held-Feindt, J. Sievers, and R. Lucius (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2021-2026
   Abstract »    Full Text »    PDF »
Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon.
M Brittan, T Hunt, R Jeffery, R Poulsom, S J Forbes, K Hodivala-Dilke, J Goldman, M R Alison, and N A Wright (2002)
Gut 50, 752-757
   Abstract »    Full Text »    PDF »
Human cord blood-derived cells attain neuronal and glial features in vitro.
L. Buzanska, E. K. Machaj, B. Zablocka, Z. Pojda, and K. Domanska-Janik (2002)
J. Cell Sci. 115, 2131-2138
   Abstract »    Full Text »    PDF »
The Role of Stem Cells in Skeletal and Cardiac Muscle Repair.
M. D. Grounds, J. D. White, N. Rosenthal, and M. A. Bogoyevitch (2002)
J. Histochem. Cytochem. 50, 589-610
   Abstract »    Full Text »    PDF »
Germ Line Stem Cell Competition in Postnatal Mouse Testes.
T. Shinohara, K. E. Orwig, M. R. Avarbock, and R. L. Brinster (2002)
Biol Reprod 66, 1491-1497
   Abstract »    Full Text »
Differentiation plasticity of hematopoietic cells.
T. Graf (2002)
Blood 99, 3089-3101
   Full Text »    PDF »
Is transdifferentiation in trouble?.
W. A. Wells (2002)
J. Cell Biol. 157, 15-18
   Abstract »    Full Text »    PDF »
Muscle-derived hematopoietic stem cells are hematopoietic in origin.
S. L. McKinney-Freeman, K. A. Jackson, F. D. Camargo, G. Ferrari, F. Mavilio, and M. A. Goodell (2002)
PNAS 99, 1341-1346
   Abstract »    Full Text »    PDF »
Human embryo research in France.
S. Viville and Y. Menezo (2002)
Hum. Reprod. 17, 261-263
   Abstract »    Full Text »    PDF »
Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones.
C. Schaniel, L. Bruno, F. Melchers, and A. G. Rolink (2002)
Blood 99, 472-478
   Abstract »    Full Text »    PDF »
The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues.
M. G. Minasi, M. Riminucci, L. De Angelis, U. Borello, B. Berarducci, A. Innocenzi, A. Caprioli, D. Sirabella, M. Baiocchi, R. De Maria, et al. (2002)
Development 129, 2773-2783
   Abstract »    Full Text »    PDF »
Quantitation and functional characterization of neural cells derived from ES cells using nestin enhancer-mediated targeting in vitro.
N. Lenka, Z. J. Lu, P. Sasse, J. Hescheler, and B. K. Fleischmann (2002)
J. Cell Sci. 115, 1471-1485
   Abstract »    Full Text »    PDF »
Stem cells for all seasons? Experimental and clinical issues.
S. Eridani (2002)
J R Soc Med 95, 5-8
   Full Text »    PDF »
The Fate of Heterotopically Grafted Neural Precursor Cells in the Normal and Dystrophic Adult Mouse Retina.
S. Pressmar, M. Ader, G. Richard, M. Schachner, and U. Bartsch (2001)
Invest. Ophthalmol. Vis. Sci. 42, 3311-3319
   Abstract »    Full Text »    PDF »
Physiological Migration of Hematopoietic Stem and Progenitor Cells.
D. E. Wright, A. J. Wagers, A. P. Gulati, F. L. Johnson, and I. L. Weissman (2001)
Science 294, 1933-1936
   Abstract »    Full Text »    PDF »
Identification of a candidate human neurohematopoietic stem-cell population.
C.-C. Shih, Y. Weng, A. Mamelak, T. LeBon, M. C.-T. Hu, and S. J. Forman (2001)
Blood 98, 2412-2422
   Abstract »    Full Text »    PDF »
Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle.
H. Kawada and M. Ogawa (2001)
Blood 98, 2008-2013
   Abstract »    Full Text »    PDF »
Hematopoietic colony-forming cells derived from human embryonic stem cells.
D. S. Kaufman, E. T. Hanson, R. L. Lewis, R. Auerbach, and J. A. Thomson (2001)
PNAS
   Abstract »    Full Text »    PDF »
Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regeneration.
G. Condorelli, U. Borello, L. De Angelis, M. Latronico, D. Sirabella, M. Coletta, R. Galli, G. Balconi, A. Follenzi, G. Frati, et al. (2001)
PNAS
   Abstract »    Full Text »    PDF »
Mobilized bone marrow cells repair the infarcted heart, improving function and survival.
D. Orlic, J. Kajstura, S. Chimenti, F. Limana, I. Jakoniuk, F. Quaini, B. Nadal-Ginard, D. M. Bodine, A. Leri, and P. Anversa (2001)
PNAS
   Abstract »    Full Text »    PDF »
Stem Cells: A Journey into a New Frontier.
B. E. PETERSEN and N. TERADA (2001)
J. Am. Soc. Nephrol. 12, 1773-1780
   Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)