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Science 22 January 1999:
Vol. 283. no. 5401, pp. 534 - 537
DOI: 10.1126/science.283.5401.534
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Reports

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

Christopher R. R. Bjornson, *dagger ddagger Rodney L. Rietze, *§ Brent A. Reynolds, M. Cristina Magli, Angelo L. Vescovi ddagger

Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.

C. R. R. Bjornson, R. L. Rietze, B. A. Reynolds, NeuroSpheres Limited, 3330 Hospital Drive Northwest, Calgary, AB, Canada T2N 4N1. M. C. Magli, Istituto di Mutagenesi, Consiglio Nazionale Recerche, Via Svezia 2/A, Pisa, Italy I-56124. A. L. Vescovi, Neurospheres Limited, 3330 Hospital Drive Northwest, Calgary, AB, Canada T2N 4N1, and Istituto Nazionale Neurologico C. Besta, Via Celoria 11, Milan, Italy I-20133.
*   These authors contributed equally to this work.

dagger    Present address: University of Washington, Department of Biochemistry, Seattle, WA 98195-7350, USA.

ddagger    To whom correspondence should be addressed at University of Washington, Department of Biochemistry, Seattle, WA 98195-7350, USA, e-mail: adanac{at}u.washington.edu (for C.R.R.B.) and at Istituto Nazionale Neurologico C. Besta, Via Celoria 11, Milan, Italy I-20133, e-mail: vescovi{at}istituto-besta.it (for A.L.V.).

§   Present address: Walter Eliza Hall Institute, Medical Research, Parkville, Victoria, Australia 3050. 

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G. Condorelli, U. Borello, L. De Angelis, M. Latronico, D. Sirabella, M. Coletta, R. Galli, G. Balconi, A. Follenzi, G. Frati, et al. (2001)
PNAS
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Mobilized bone marrow cells repair the infarcted heart, improving function and survival.
D. Orlic, J. Kajstura, S. Chimenti, F. Limana, I. Jakoniuk, F. Quaini, B. Nadal-Ginard, D. M. Bodine, A. Leri, and P. Anversa (2001)
PNAS
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Stem Cells: A Journey into a New Frontier.
B. E. PETERSEN and N. TERADA (2001)
J. Am. Soc. Nephrol. 12, 1773-1780
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Science. ISSN 0036-8075 (print), 1095-9203 (online)