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Science 20 August 1943:
Vol. 98. no. 2538, pp. 179 - 182
DOI: 10.1126/science.98.2538.179
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Articles

THE PRODUCTION OF FOLIC ACID BY RAT LIVER IN VITRO

LEMUEL D. WRIGHT 1 and ARNOLD D. WELCH 1

1 NUTRITIONAL LABORATORIES, DEPARTMENT OF PHARMACOLOGY, MEDICAL-RESEARCH DIVISION, SHARP AND DOHME, INC., GLENOLDEN, PA.

The occurrence in urine and in acid-autoclaved grass and liver extracts of a substance which appears to participate in the synthesis of folic acid by rat liver in vitro is described. A similar effect is produced by synthetic xanthopterin. The effect of these materials might be accomplished by (1) catalysis of the enzymatic synthesis of folic acid; (2) the release of folic acid not liberated by takadiastase from tissue complexes; or (3) their serving as substrate material for the enzymatic synthesis of folic acid. The data presented favor the last hypothesis and suggest that xanthopterin, or a substance derived from it, may constitute a portion of the folic acid molecule. The probable involvement of compounds related to ranthopterin in the formation of hemocytopoietic substances in several animal species is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Labile Precursor of Citrovorum Factor.
C. A. Nichol, A. H. Anton, and S. F. Zakrzewski (1955)
Science 121, 275-279
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THE EFFECT OF ATROPINE SULFATE ON THE COURSE OF INFLUENZA VIRUS INFECTION.
A. H. WHEELER and W. J. NUNGESTER (1944)
Science 100, 523-524
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FURTHER STUDIES ON THE RELATIONSHIP BETWEEN XANTHOPTERIN, FOLIC ACID AND VITAMIN M.
J. R. TOTTER, V. MIMS, and P. L. DAY (1944)
Science 100, 223-225
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BLOOD: A REVIEW OF THE RECENT LITERATURE.
F. H. BETHELL, C. C. STURGIS, O. T. MALLERY Jr., and R. W. RUNDLES (1944)
Arch Intern Med 74, 131-152
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