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Science 19 January 1940:
Vol. 91. no. 2351, pp. 58 - 62
DOI: 10.1126/science.91.2351.58
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Articles

VITAMIN K

E. A. DOISY 1, S. B. BINKLEY 1, S. A. THAYER 1, and R. W. MCKEE 1

1 DEPARTMENT OF BIOCHEMISTRY, SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE, SAINT LOUIS, MO

During the decade following Dam's first observations on the hemorrhagic syndrome the combined efforts of several groups of investigators have solved many of the important problems connected with the new vitamin. Sources of vitamin K were discovered, methods of extraction and purification devised, the isolation effected, the structure of K1 worked out and then verified by synthesis, and a promising start made on the therapeutic applications. In addition, simple water soluble compounds with antihemorrhagic properties have been supplied for clinical work. Preliminary results with these compounds are encouraging.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
LIVER AND BILIARY TRACT A REVIEW FOR 1939.
C. H. GREENE and E. FARRELL (1940)
Arch Intern Med 65, 847-869
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