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Science 9 October 2009:
Vol. 326. no. 5950, p. 230
DOI: 10.1126/science.1169736
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Technical Comments

Response to Comment on "The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop"

Antony N. Dodd,* Michael J. Gardner, Carlos T. Hotta, Katharine E. Hubbard, Neil Dalchau, Fiona C. Robertson, John Love,{dagger} Dale Sanders,* Alex A. R. Webb{ddagger}

Xu et al. were unable to measure circadian oscillations of cyclic adenosine diphosphate ribose (cADPR). Their experiments showing very low concentrations of cADPR lack appropriate controls, which suggests that technical limitations might explain their negative result. Xu et al. also report that chemically induced ADP ribosyl cyclase did not alter clock function, which exactly replicates our findings.

Department of Plant Sciences, Downing Street, Cambridge CB2 3EA, UK.

* Present address: Department of Biology, University of York, York YO10 5YW, UK.

{dagger} Present address: School of Biosciences, University of Exeter, Exeter EX4 4QD, UK.

{ddagger} To whom correspondence should be addressed. E-mail: alex.webb{at}plantsci.cam.ac.uk

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