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Science 9 October 2009:
Vol. 326. no. 5950, p. 230
DOI: 10.1126/science.1169503
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Technical Comments

Comment on "The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop"

Xiaodong Xu,1,* Richard Graeff,2 Qiguang Xie,1,* Karen L. Gamble,1 Tetsuya Mori,1 Carl Hirschie Johnson1,{dagger}

Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR). In contrast, we found that there is no rhythm of cADPR levels nor are there any significant effects on the rhythm by cADPR overexpression, thus raising questions about the conclusions of Dodd et al.

1 Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.
2 Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.

* Present address: Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.

{dagger} To whom correspondence should be addressed. E-mail: carl.h.johnson{at}vanderbilt.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Response to Comment on "The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop".
A. N. Dodd, M. J. Gardner, C. T. Hotta, K. E. Hubbard, N. Dalchau, F. C. Robertson, J. Love, D. Sanders, and A. A. R. Webb (2009)
Science 326, 230
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