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Science 7 August 2009:
Vol. 325. no. 5941, pp. 725 - 730
DOI: 10.1126/science.1174251
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Reports

Folding DNA into Twisted and Curved Nanoscale Shapes

Hendrik Dietz,1,2,* Shawn M. Douglas,1,2,3 William M. Shih1,2,3,{dagger}

We demonstrate the ability to engineer complex shapes that twist and curve at the nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to form a custom-shaped bundle of tightly cross-linked double helices, arrayed in parallel to their helical axes. Targeted insertions and deletions of base pairs cause the DNA bundles to develop twist of either handedness or to curve. The degree of curvature could be quantitatively controlled, and a radius of curvature as tight as 6 nanometers was achieved. We also combined multiple curved elements to build several different types of intricate nanostructures, such as a wireframe beach ball or square-toothed gears.

1 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
3 Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.

* Present address: Physik Department and CiPSM, Technische Universität München, D-85748 Garching bei München, Germany.

{dagger} To whom correspondence should be addressed. E-mail: william_shih{at}dfci.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Designer Curvature.
Y. Liu and H. Yan (2009)
Science 325, 685-686
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