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Science 31 July 2009:
Vol. 325. no. 5940, p. 538
DOI: 10.1126/science.1168786
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Technical Comments

Comment on "Remeasuring the Double Helix"

Nils B. Becker and Ralf Everaers*

Mathew-Fenn et al. (Reports, 17 October 2008, p. 446) reported unexpected distance fluctuations in short end-labeled DNA constructs and interpreted them as evidence for cooperative DNA stretching modes. We show that when accounting for a subtle linker leverage effect, their data can be understood within standard noncooperative DNA elasticity.

Centre Blaise Pascal et Laboratoire de Physique, CNRS UMR 5672, École Normale Supérieure, Université de Lyon, 46 Allée d’Italie, 69007 Lyon, France.

* To whom correspondence should be addressed. E-mail: ralf.everaers{at}ens-lyons.fr

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Science. ISSN 0036-8075 (print), 1095-9203 (online)