Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 April 2009:
Vol. 324. no. 5924, pp. 198 - 203
DOI: 10.1126/science.1169377
Prev | Table of Contents | Next

Review

Sending Signals Dynamically

Robert G. Smock and Lila M. Gierasch

Proteins mediate transmission of signals along intercellular and intracellular pathways and between the exterior and the interior of a cell. The dynamic properties of signaling proteins are crucial to their functions. We discuss emerging paradigms for the role of protein dynamics in signaling. A central tenet is that proteins fluctuate among many states on evolutionarily selected energy landscapes. Upstream signals remodel this landscape, causing signaling proteins to transmit information to downstream partners. New methods provide insight into the dynamic properties of signaling proteins at the atomic scale. The next stages in the signaling hierarchy—how multiple signals are integrated and how cellular signaling pathways are organized in space and time—present exciting challenges for the future, requiring bold multidisciplinary approaches.

Department of Biochemistry and Molecular Biology and Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA. E-mail: gierasch{at}biochem.umass.edu (L.M.G.); rsmock{at}student.umass.edu (R.G.S.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ELM: the status of the 2010 eukaryotic linear motif resource.
C. M. Gould, F. Diella, A. Via, P. Puntervoll, C. Gemund, S. Chabanis-Davidson, S. Michael, A. Sayadi, J. C. Bryne, C. Chica, et al. (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1.
H. Zhang, J.-h. Liu, W. Yang, T. Springer, M. Shimaoka, and J.-h. Wang (2009)
PNAS 106, 18345-18350
   Abstract »    Full Text »    PDF »
The Vitamin D Sterol-Vitamin D Receptor Ensemble Model Offers Unique Insights into Both Genomic and Rapid-Response Signaling.
M. T. Mizwicki and A. W. Norman (2009)
Science Signaling 2, re4
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)