Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 November 2008:
Vol. 322. no. 5906, pp. 1384 - 1387
DOI: 10.1126/science.1164216
Prev | Table of Contents | Next

Reports

Chromosome Alignment and Transvection Are Antagonized by Condensin II

Tom A. Hartl, Helen F. Smith, Giovanni Bosco*

Polytene chromosome structure is a characteristic of some polyploid cells where several to thousands of chromatids are closely associated with perfect alignment of homologous DNA sequences. Here, we show that Drosophila condensin II promotes disassembly of polytene structure into chromosomal components. Condensin II also negatively regulates transvection, a process whereby certain alleles are influenced transcriptionally via interallelic physical associations. We propose that condensin II restricts trans-chromosomal interactions that affect transcription through its ability to spatially separate aligned interphase chromosomes.

Department of Molecular and Cellular Biology, University of Arizona, 1007 East Lowell Street, Tucson, AZ 85721–0106, USA.

* To whom correspondence should be addressed. E-mail: gbosco{at}email.arizona.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of Chromosomal Rearrangements on Transvection at the yellow Gene of Drosophila melanogaster.
S. A. Ou, E. Chang, S. Lee, K. So, C.-t. Wu, and J. R. Morris (2009)
Genetics 183, 483-496
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)