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David Altshuler,1,2,3,4,5*Mark J. Daly,1,2,5*Eric S. Lander1,6,7,8*
Genetic mapping provides a powerful approach to identify genesand biological processes underlying any trait influenced byinheritance, including human diseases. We discuss the intellectualfoundations of genetic mapping of Mendelian and complex traitsin humans, examine lessons emerging from linkage analysis ofMendelian diseases and genome-wide association studies of commondiseases, and discuss questions and challenges that lie ahead.
1 Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. 2 Center for Human Genetic Research and Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. 3 Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. 4 Department of Genetics, Harvard Medical School, Boston, MA 02114, USA. 5 Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. 6 Department of Systems Biology, Harvard Medical School, Boston, MA 02114, USA. 7 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. 8 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
* To whom correspondence should be addressed. E-mail: altshuler{at}molbio.mgh.harvard.edu (D.A.); mjdaly{at}chgr.mgh.harvard.edu (M.J.D.); lander{at}broad.mit.edu (E.S.L.)
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