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Science 31 October 2008:
Vol. 322. no. 5902, p. 675
DOI: 10.1126/science.1161284
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Technical Comments

Comment on "Differential Rescue of Light- and Food-Entrainable Circadian Rhythms"

Ralph E. Mistlberger,1* Shin Yamazaki,2 Julie S. Pendergast,2 Glenn J. Landry,1 Toru Takumi,3 Wataru Nakamura3

Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1–/– mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.

1 Department of Psychology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
2 Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235–1634, USA.
3 Osaka Bioscience Institute, Osaka 565-0874, Japan.

* To whom correspondence should be addressed. E-mail: mistlber{at}sfu.ca

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Science. ISSN 0036-8075 (print), 1095-9203 (online)