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Science 17 October 2008:
Vol. 322. no. 5900, pp. 421 - 424
DOI: 10.1126/science.1163242
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Reports

Accurate Temperature Imaging Based on Intermolecular Coherences in Magnetic Resonance

Gigi Galiana,1,2 Rosa T. Branca,2 Elizabeth R. Jenista,2 Warren S. Warren2*

Conventional magnetic resonance methods that provide interior temperature profiles, which find use in clinical applications such as hyperthermic therapy, can develop inaccuracies caused by the inherently inhomogeneous magnetic field within tissues or by probe dynamics, and work poorly in important applications such as fatty tissues. We present a magnetic resonance method that is suitable for imaging temperature in a wide range of environments. It uses the inherently sharp resonances of intermolecular zero-quantum coherences, in this case flipping up a water spin while flipping down a nearby fat spin. We show that this method can rapidly and accurately assign temperatures in vivo on an absolute scale.

1 Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
2 Center for Molecular and Biomolecular Imaging, Duke University, Durham, NC 27708, USA.

* To whom correspondence should be addressed. E-mail: warren.warren{at}duke.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two-Quantum 2D FT Electronic Spectroscopy of Biexcitons in GaAs Quantum Wells.
K. W. Stone, K. Gundogdu, D. B. Turner, X. Li, S. T. Cundiff, and K. A. Nelson (2009)
Science 324, 1169-1173
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