Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 17 October 2008:
Vol. 322. no. 5900, pp. 390 - 395
DOI: 10.1126/science.1160617
Prev | Table of Contents | Next

Review

Feedback Loops Shape Cellular Signals in Space and Time

Onn Brandman1 and Tobias Meyer2

Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.

1 Department of Cellular and Molecular Pharmacology, University of California-San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA. E-mail: Onn.Brandman{at}ucsf.edu
2 Department of Chemical and Systems Biology, 318 Campus Drive, Clark Building W200, Stanford University Medical Center, Stanford, CA 94305–5174, USA. E-mail: tobias1{at}stanford.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.
Y. Harita, H. Kurihara, H. Kosako, T. Tezuka, T. Sekine, T. Igarashi, I. Ohsawa, S. Ohta, and S. Hattori (2009)
J. Biol. Chem. 284, 8951-8962
   Abstract »    Full Text »    PDF »
Ca2+-Calmodulin Feedback Mediates Sensory Adaptation and Inhibits Pheromone-Sensitive Ion Channels in the Vomeronasal Organ.
J. Spehr, S. Hagendorf, J. Weiss, M. Spehr, T. Leinders-Zufall, and F. Zufall (2009)
J. Neurosci. 29, 2125-2135
   Abstract »    Full Text »    PDF »
From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology.
J. Lewis (2008)
Science 322, 399-403
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)