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Science 5 September 2008:
Vol. 321. no. 5894, p. 1314
DOI: 10.1126/science.1160631
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Brevia

Shadow Enhancers as a Source of Evolutionary Novelty

Joung-Woo Hong, David A. Hendrix, Michael S. Levine*

Some developmentally important genes can be regulated via two enhancers, one located nearby and the other, a "shadow" enhancer, 10 to 20 kilobases away.

Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA.

* To whom correspondence should be addressed. E-mail: mlevine{at}berkeley.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)