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Science 22 August 2008:
Vol. 321. no. 5892, p. 1040
DOI: 10.1126/science.1157829
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Technical Comments

Response to Comment on "Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry"

John M. Asara,1,2* Mary H. Schweitzer,3 Lewis C. Cantley,1,2 John S. Cottrell4

Endogenous peptide sequences extracted from a 68-million-year-old Tyrannosaurus rex fossil bone and obtained by mass spectrometry have been shown to be statistically significant based on protein database searches using two different search engines and similarity comparisons to authentic tandem mass spectrometry spectra. Specifically, we have validated the sequence GVVGLP(OH)GQR.

1 Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
2 Harvard Medical School, Boston, MA 02115, USA.
3 North Carolina State University, Raleigh, NC 27695, USA.
4 Matrix Science Ltd., London, UK.

* To whom correspondence should be addressed. E-mail: jasara{at}bidmc.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis.
M. H. Schweitzer, W. Zheng, C. L. Organ, R. Avci, Z. Suo, L. M. Freimark, V. S. Lebleu, M. B. Duncan, M. G. Vander Heiden, J. M. Neveu, et al. (2009)
Science 324, 626-631
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Science. ISSN 0036-8075 (print), 1095-9203 (online)