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Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity
Weixing Shen,1Marc Flajolet,2Paul Greengard,2D. James Surmeier1*
At synapses between cortical pyramidal neurons and principalstriatal medium spiny neurons (MSNs), postsynaptic D1 and D2dopamine (DA) receptors are postulated to be necessary for theinduction of long-term potentiation and depression, respectively—formsof plasticity thought to underlie associative learning. Becausethese receptors are restricted to two distinct MSN populations,this postulate demands that synaptic plasticity be unidirectionalin each cell type. Using brain slices from DA receptor transgenicmice, we show that this is not the case. Rather, DA plays complementaryroles in these two types of MSN to ensure that synaptic plasticityis bidirectional and Hebbian. In models of Parkinson's disease,this system is thrown out of balance, leading to unidirectionalchanges in plasticity that could underlie network pathologyand symptoms.
1 Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. 2 Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
* To whom correspondence should be addressed. E-mail: j-surmeier{at}northwestern.edu
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