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Science 1 August 2008:
Vol. 321. no. 5889, p. 640
DOI: 10.1126/science.1156889
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Technical Comments

Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"

Petar M. Djuric,1* Helene Benveniste,1,2 Mark E. Wagshul,1 Fritz Henn,2 Grigori Enikolopov,3 Mirjana Maletic-Savatic1,3*

We reported on a neural progenitor cell biomarker, a lipid-based metabolite enriched in these cells, which we detected using spectroscopy both in vitro and in vivo, and singular value decomposition–based signal processing. The study provided an outline of our computational methodology. Herein, we report more extensively on the method of spectrum analysis used, demonstrating the specificity of our findings.

1 Stony Brook University, Stony Brook, NY 11794, USA.
2 Brookhaven National Laboratory, Brookhaven, NY 11719, USA.
3 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

* To whom correspondence should be addressed. E-mail: djuric{at}ece.sunysb.edu (P.M.D.); Mirjana.Maletic-Savatic{at}stonybrook.edu (M.M.-S.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)