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Science 1 August 2008:
Vol. 321. no. 5889, p. 640
DOI: 10.1126/science.1153058
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Technical Comments

Comment on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain"

Jeffrey C. Hoch,* Mark W. Maciejewski, Michael R. Gryk

Manganas et al. (Reports, 9 November 2007, p. 980) used nuclear magnetic resonance spectroscopy to identify a biomarker of neural progenitor cells. However, their analysis relies on spectral processing methods that are known to be problematic. Absent detection using alternate methods of spectrum analysis or controls to quantify the false discovery rate, their conclusions may be premature.

Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030–3305, USA.

* To whom correspondence should be addressed. E-mail: hoch{at}uchc.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)