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Science 18 July 2008:
Vol. 321. no. 5887, p. 342
DOI: 10.1126/science.1158879
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Technical Comments

Response to Comment on "A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea"

Ivan A. Berg,1 Daniel Kockelkorn,1 Wolfgang Buckel,2 Georg Fuchs1*

We proposed that the 3-hydroxypropionate/4-hydroxybutyrate cycle might be important in global carbon cycling based on the abundance of related autotrophic Crenarchaea in the ocean and the high number of gene sequences for a key enzyme of the cycle. Here, we counter the specific criticisms raised by Ettema and Andersson.

1 Mikrobiologie, Fakultät Biologie, Universität Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany.
2 Mikrobiologie, Fachbereich Biologie, Universität Marburg, D-35032 Marburg, Germany.

* To whom correspondence should be addressed. E-mail: georg.fuchs{at}biologie.uni-freiburg.de

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Science. ISSN 0036-8075 (print), 1095-9203 (online)