Response to Comment on "Genetically Determined Differences in Learning from Errors"
Tilmann A. Klein,1*
Martin Reuter,2
D. Yves von Cramon,1,3
Markus Ullsperger1,3*
Since the publication of our findings, further genetic and pharmacological
studies have bolstered our conclusion that dopamine D2 receptors
are essential for performance monitoring and learning. Although
the functionally complex dopamine D2 receptor gene polymorphism
DRD2-TAQ-IA may also affect cellular signaling components, the
accumulated evidence supports the notion that our findings were
mediated by differential D2 receptor density.
2 Department of Psychology, University of Bonn, Bonn 53117, Germany.
3 Max Planck Institute for Neurological Research, Cologne 50931, Germany.
* To whom correspondence should be addressed. E-mail: tklein{at}cbs.mpg.de (T.A.K.); ullsperger{at}nf.mpg.de (M.U.)
