Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Originally published in Science Express on 24 April 2008
Science 30 May 2008:
Vol. 320. no. 5880, pp. 1220 - 1224
DOI: 10.1126/science.1155209
Prev | Table of Contents | Next

Reports

Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells

Jennifer M. Lund, Lianne Hsing, Thuy T. Pham, Alexander Y. Rudensky*

Suppression of immune responses by regulatory T cells (Tregs) is thought to limit late stages of pathogen-specific immunity as a means of minimizing associated tissue damage. We examined a role for Tregs during mucosal herpes simplex virus infection in mice, and observed an accelerated fatal infection with increased viral loads in the mucosa and central nervous system after ablation of Tregs. Although augmented interferon production was detected in the draining lymph nodes (dLNs) in Treg-deprived mice, it was profoundly reduced at the infection site. This was associated with a delay in the arrival of natural killer cells, dendritic cells, and T cells to the site of infection and a sharp increase in proinflammatory chemokine levels in the dLNs. Our results suggest that Tregs facilitate early protective responses to local viral infection by allowing a timely entry of immune cells into infected tissue.

Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

* To whom correspondence should be addressed. E-mail: aruden{at}u.washington.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells.
W. E. O'Gorman, H. Dooms, S. H. Thorne, W. F. Kuswanto, E. F. Simonds, P. O. Krutzik, G. P. Nolan, and A. K. Abbas (2009)
J. Immunol. 183, 332-339
   Abstract »    Full Text »    PDF »
GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo.
R. W. van Olffen, N. Koning, K. P. J. M. van Gisbergen, F. M. Wensveen, R. M. Hoek, L. Boon, J. Hamann, R. A. W. van Lier, and M. A. Nolte (2009)
J. Immunol. 182, 7490-7500
   Abstract »    Full Text »    PDF »
How Diverse--CD4 Effector T Cells and their Functions.
Y. Y. Wan and R. A. Flavell (2009)
J Mol Cell Biol
   Abstract »    Full Text »    PDF »
Regulatory T Cells Promote Early Influx of CD8+ T Cells in the Lungs of Respiratory Syncytial Virus-Infected Mice and Diminish Immunodominance Disparities.
T. J. Ruckwardt, K. L. Bonaparte, M. C. Nason, and B. S. Graham (2009)
J. Virol. 83, 3019-3028
   Abstract »    Full Text »    PDF »
Anti-CD25 Antibody-Mediated Depletion of Effector T Cell Populations Enhances Susceptibility of Mice to Acute but Not Chronic Toxoplasma gondii Infection.
K. N. Couper, P. A. Lanthier, G. Perona-Wright, L. W. Kummer, W. Chen, S. T. Smiley, M. Mohrs, and L. L. Johnson (2009)
J. Immunol. 182, 3985-3994
   Abstract »    Full Text »    PDF »
FoxP3+ Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions.
C. Taflin, M. Miyara, D. Nochy, D. Valeyre, J.-M. Naccache, F. Altare, P. Salek-Peyron, C. Badoual, P. Bruneval, J. Haroche, et al. (2009)
Am. J. Pathol. 174, 497-508
   Abstract »    Full Text »    PDF »
Intratumoral Immune Cell Infiltrates, FoxP3, and Indoleamine 2,3-Dioxygenase in Patients with Melanoma Undergoing CTLA4 Blockade.
A. Ribas, B. Comin-Anduix, J. S. Economou, T. R. Donahue, P. de la Rocha, L. F. Morris, J. Jalil, V. B. Dissette, I. P. Shintaku, J. A. Glaspy, et al. (2009)
Clin. Cancer Res. 15, 390-399
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)