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Science 23 May 2008:
Vol. 320. no. 5879, p. 1012
DOI: 10.1126/science.1152620
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Technical Comments

Response to Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"

Akiko Taguchi and Morris F. White*

Differences in reported life span of mice heterozygous for a null allele of the insulin receptor substrate–2 (Irs2) might involve the effects of diet, breeding strategies, and genetic background on insulin-like signaling cascades. A better understanding will emerge from studies focusing on the coordination of nutrient homeostasis and life span by insulin-like signaling in specific peripheral tissues and the central nervous system.

Howard Hughes Medical Institute, Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

* To whom correspondence should be addressed. E-mail: morris.white{at}childrens.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)