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Science 23 May 2008:
Vol. 320. no. 5879, p. 1012
DOI: 10.1126/science.1152366
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Technical Comments

Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"

Colin Selman,1 Steven Lingard,1 David Gems,2 Linda Partridge,2 Dominic J. Withers1*

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

1 Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK.
2 Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.

* To whom correspondence should be addressed. E-mail: d.withers{at}ucl.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)