Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 March 2008:
Vol. 319. no. 5871, pp. 1787 - 1789
DOI: 10.1126/science.1155472

Perspective

The Eukaryotic Genome as an RNA Machine

Paulo P. Amaral, Marcel E. Dinger, Tim R. Mercer, John S. Mattick*

The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non–protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.

Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia.

* To whom correspondence should be addressed. E-mail: j.mattick{at}imb.uq.edu.au

Read the Full Text



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Conserved introns reveal novel transcripts in Drosophila melanogaster.
M. Hiller, S. Findeiss, S. Lein, M. Marz, C. Nickel, D. Rose, C. Schulz, R. Backofen, S. J. Prohaska, G. Reuter, et al. (2009)
Genome Res. 19, 1289-1300
   Abstract »    Full Text »    PDF »
Estradiol-regulated microRNAs control estradiol response in breast cancer cells.
P. Bhat-Nakshatri, G. Wang, N. R. Collins, M. J. Thomson, T. R. Geistlinger, J. S. Carroll, M. Brown, S. Hammond, E. F. Srour, Y. Liu, et al. (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Small regulatory RNAs in neurodevelopmental disorders.
S. Chang, S. Wen, D. Chen, and P. Jin (2009)
Hum. Mol. Genet. 18, R18-R26
   Abstract »    Full Text »    PDF »
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation.
G. H. S. Richter, S. Plehm, A. Fasan, S. Rossler, R. Unland, I. M. Bennani-Baiti, M. Hotfilder, D. Lowel, I. von Luettichau, I. Mossbrugger, et al. (2009)
PNAS 106, 5324-5329
   Abstract »    Full Text »    PDF »
Darwinian evolution in the light of genomics.
E. V. Koonin (2009)
Nucleic Acids Res. 37, 1011-1034
   Abstract »    Full Text »    PDF »
MEN{varepsilon}/{beta} noncoding RNAs are essential for structural integrity of nuclear paraspeckles.
Y. T. F. Sasaki, T. Ideue, M. Sano, T. Mituyama, and T. Hirose (2009)
PNAS 106, 2525-2530
   Abstract »    Full Text »    PDF »
The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA.
C. P. Keating, M. K. Hill, D. J. Hawkes, R. P. Smyth, C. Isel, S.-Y. Le, A. C. Palmenberg, J. A. Marshall, R. Marquet, G. J. Nabel, et al. (2009)
Nucleic Acids Res. 37, 945-956
   Abstract »    Full Text »    PDF »
NRED: a database of long noncoding RNA expression.
M. E. Dinger, K. C. Pang, T. R. Mercer, M. L. Crowe, S. M. Grimmond, and J. S. Mattick (2009)
Nucleic Acids Res. 37, D122-D126
   Abstract »    Full Text »    PDF »
A rugged free energy landscape separates multiple functional RNA folds throughout denaturation.
M. A. Ditzler, D. Rueda, J. Mo, K. Hakansson, and N. G. Walter (2008)
Nucleic Acids Res. 36, 7088-7099
   Abstract »    Full Text »    PDF »
Mapping Key Features of Transcriptional Regulatory Circuitry in Embryonic Stem Cells.
M.F. Cole and R.A. Young (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Noncoding RNAs in Long-Term Memory Formation.
T. R. Mercer, M. E. Dinger, J. Mariani, K. S. Kosik, M. F. Mehler, and J. S. Mattick (2008)
Neuroscientist 14, 434-445
   Abstract »    PDF »
MicroRNAs: components of an integrated system controlling cardiac development, physiology, and disease pathogenesis.
G. Condorelli and S. Dimmeler (2008)
Cardiovasc Res 79, 551-552
   Full Text »    PDF »
Tilting at Quixotic Trait Loci (QTL): An Evolutionary Perspective on Genetic Causation.
K. M. Weiss (2008)
Genetics 179, 1741-1756
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)