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ReportsMembrane Proteins of the Endoplasmic Reticulum Induce High-Curvature Tubules
The tubular structure of the endoplasmic reticulum (ER) appears to be generated by integral membrane proteins, the reticulons and a protein family consisting of DP1 in mammals and Yop1p in yeast. Here, individual members of these families were found to be sufficient to generate membrane tubules. When we purified yeast Yop1p and incorporated it into proteoliposomes, narrow tubules (
1 Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. * To whom correspondence should be addressed. E-mail: tom_rapoport{at}hms.harvard.edu (T.A.R.); wprinz{at}helix.nih.gov (W.A.P.)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)