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Science 25 January 2008:
Vol. 319. no. 5862, pp. 462 - 465
DOI: 10.1126/science.1150987
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Reports

Control of Genic DNA Methylation by a jmjC Domain-Containing Protein in Arabidopsis thaliana

Hidetoshi Saze,* Akiko Shiraishi, Asuka Miura, Tetsuji Kakutani

Differential cytosine methylation of repeats and genes is important for coordination of genome stability and proper gene expression. Through genetic screen of mutants showing ectopic cytosine methylation in a genic region, we identified a jmjC-domain gene, IBM1 (increase in bonsai methylation 1), in Arabidopsis thaliana. In addition to the ectopic cytosine methylation, the ibm1 mutations induced a variety of developmental phenotypes, which depend on methylation of histone H3 at lysine 9. Paradoxically, the developmental phenotypes of the ibm1 were enhanced by the mutation in the chromatin-remodeling gene DDM1 (decrease in DNA methylation 1), which is necessary for keeping methylation and silencing of repeated heterochromatin loci. Our results demonstrate the importance of chromatin remodeling and histone modifications in the differential epigenetic control of repeats and genes.

Department of Integrated Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8540, Japan.

* To whom correspondence should be addressed. E-mail: hsaze{at}lab.nig.ac.jp

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development.
Q. Sun and D.-X. Zhou (2008)
PNAS 105, 13679-13684
   Abstract »    Full Text »    PDF »
Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading.
I. R. Henderson and S. E. Jacobsen (2008)
Genes & Dev. 22, 1597-1606
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Science. ISSN 0036-8075 (print), 1095-9203 (online)