Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 11 January 2008:
Vol. 319. no. 5860, pp. 198 - 202
DOI: 10.1126/science.1151869
Prev | Table of Contents | Next

Reports

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

Linda M. Wakim,1 Jason Waithman,1 Nico van Rooijen,2 William R. Heath,3* Francis R. Carbone1*

Secondary lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen-presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue-resident T cells during secondary challenge. The results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.

1 Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia.
2 Faculty of Medicine, Department of Molecular Cell Biology, Vrije Universiteit, 1081 BT, Amsterdam, Netherlands.
3 Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.

* To whom correspondence should be addressed. E-mail: fcarbone{at}unimelb.edu.au (F.R.C.); heath{at}wehi.edu.au (W.R.H.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effector CD4+ T-Cell Involvement in Clearance of Infectious Herpes Simplex Virus Type 1 from Sensory Ganglia and Spinal Cords.
A. J. Johnson, C.-F. Chu, and G. N. Milligan (2008)
J. Virol. 82, 9678-9688
   Abstract »    Full Text »    PDF »
Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.
J. McGill, N. Van Rooijen, and K. L. Legge (2008)
J. Exp. Med. 205, 1635-1646
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)