Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
ESF Genomics

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 11 January 2008:
Vol. 319. no. 5860, pp. 195 - 198
DOI: 10.1126/science.1150224
Prev | Table of Contents | Next

Reports

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

Dingcheng Gao, Daniel J. Nolan, Albert S. Mellick, Kathryn Bambino, Kevin McDonnell, Vivek Mittal*

Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)–derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.

Cancer Genome Research Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

* To whom correspondence should be addressed. E-mail: mittal{at}cshl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases.
D. J. Weiss, J. K. Kolls, L. A. Ortiz, A. Panoskaltsis-Mortari, and D. J. Prockop (2008)
Proceedings of the ATS 5, 637-667
   Full Text »    PDF »
Review: Endothelial progenitor cells: markers of vascular reparative capacity.
T. J. Povsic and P. J. Goldschmidt-Clermont (2008)
Therapeutic Advances in Cardiovascular Disease 2, 199-213
   Abstract »    PDF »
Tumor Angiogenesis.
R. S. Kerbel (2008)
N. Engl. J. Med. 358, 2039-2049
   Full Text »    PDF »
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.
S. Purhonen, J. Palm, D. Rossi, N. Kaskenpaa, I. Rajantie, S. Yla-Herttuala, K. Alitalo, I. L. Weissman, and P. Salven (2008)
PNAS 105, 6620-6625
   Abstract »    Full Text »    PDF »
Migratory neighbors and distant invaders: tumor-associated niche cells.
J. Wels, R. N. Kaplan, S. Rafii, and D. Lyden (2008)
Genes & Dev. 22, 559-574
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)