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Science 4 January 2008:
Vol. 319. no. 5859, p. 33
DOI: 10.1126/science.1147364
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Technical Comments

Response to Comment on "Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry"

John M. Asara1,2* and Mary H. Schweitzer3,4

We sequenced six endogenous collagen peptides from Tyrannosaurus rex bone fragments using mass spectrometry. Five sequences match birds, but only two match amphibians, supporting dinosaur-bird relationships. Buckley et al. reinterpret and misinterpret our data and question sequence authenticity, but they used a suboptimal phylogenetic algorithm to analyze only a subset of reported sequences and they suggest analyses that are less sensitive and less specific than mass spectrometry. We disagree and use data to explain.

1 Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
2 Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
3 Department of Marine, Earth, and Atmospheric Sciences, North Carolina State University, Raleigh, NC 27695, USA.
4 North Carolina Museum of Natural Sciences, Raleigh, NC 27601, USA.

* To whom correspondence should be addressed. E-mail: jasara{at}bidmc.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Response to Comment on "Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry".
J. M. Asara, M. H. Schweitzer, L. C. Cantley, and J. S. Cottrell (2008)
Science 321, 1040c
   Abstract »    Full Text »    PDF »
Molecular Phylogenetics of Mastodon and Tyrannosaurus rex.
C. L. Organ, M. H. Schweitzer, W. Zheng, L. M. Freimark, L. C. Cantley, and J. M. Asara (2008)
Science 320, 499
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)