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Science 14 December 2007:
Vol. 318. no. 5857, p. 1722
DOI: 10.1126/science.1149672
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Technical Comments

Response to Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"

Jerry M. Adams,1* Priscilla N. Kelly,1,2 Aleksandar Dakic,1,2 Stephen L. Nutt,1 Andreas Strasser1*

A critical issue for cancer biology and therapy is whether most tumor cells or only rare "cancer stem cells" sustain tumor growth. Although the latter model seems supported by the minute proportion of human leukemia cells that can grow in immunodeficient mice, evidence that more than 10% of cells in many mouse leukemias and lymphomas are transplantable challenges its generality.

1 Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia.
2 Department of Medical Biology, University of Melbourne, Melbourne 3050, Australia.

* To whom correspondence should be addressed. E-mail: adams{at}wehi.edu.au (J.M.A.); strasser{at}wehi.edu.au (A.S.)

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