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Science 30 November 2007:
Vol. 318. no. 5855, pp. 1412 - 1416
DOI: 10.1126/science.1142204
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Review

Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport

Laura J. Terry, Eric B. Shows, Susan R. Wente*

Transport of macromolecules between the nucleus and cytoplasm is a critical cellular process for eukaryotes, and the machinery that mediates nucleocytoplasmic exchange is subject to multiple levels of control. Regulation is achieved by modulating the expression or function of single cargoes, transport receptors, or the transport channel. Each of these mechanisms has increasingly broad impacts on transport patterns and capacity, and this hierarchy of control directly affects gene expression, signal transduction, development, and disease.

Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

* To whom correspondence should be addressed. E-mail: susan.wente{at}vanderbilt.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)