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Science 30 November 2007:
Vol. 318. no. 5855, pp. 1408 - 1412
DOI: 10.1126/science.1142034
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Review

Blurring the Boundary: The Nuclear Envelope Extends Its Reach

Colin L. Stewart,1 Kyle J. Roux,2 Brian Burke2*

The past decade has seen a complete rethinking of the traditional view of the nuclear envelope as simply a passive enclosure for the chromosomes. The convergence of several lines of clinical and basic research has revealed additional roles in both signaling and mitotic progression. It is becoming apparent that the nuclear envelope defines not only nuclear organization but also that of the cytoskeleton and, in this way, integrates both nuclear and cytoplasmic architecture.

1 Institute of Medical Biology, 61 Biopolis Drive, Proteos, Singapore 138668, Singapore.
2 Department of Anatomy and Cell Biology, The University of Florida, 1600 Southwest Archer Road, Gainesville, FL 32610–0235, USA.

* To whom correspondence should be addressed. E-mail. bburke{at}ufl.edu

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