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Blurring the Boundary: The Nuclear Envelope Extends Its Reach
Colin L. Stewart,1Kyle J. Roux,2Brian Burke2*
The past decade has seen a complete rethinking of the traditionalview of the nuclear envelope as simply a passive enclosure forthe chromosomes. The convergence of several lines of clinicaland basic research has revealed additional roles in both signalingand mitotic progression. It is becoming apparent that the nuclearenvelope defines not only nuclear organization but also thatof the cytoskeleton and, in this way, integrates both nuclearand cytoplasmic architecture.
1 Institute of Medical Biology, 61 Biopolis Drive, Proteos, Singapore 138668, Singapore. 2 Department of Anatomy and Cell Biology, The University of Florida, 1600 Southwest Archer Road, Gainesville, FL 32610–0235, USA.
* To whom correspondence should be addressed. E-mail. bburke{at}ufl.edu
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