Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 November 2007:
Vol. 318. no. 5853, pp. 1147 - 1150
DOI: 10.1126/science.1148979
Prev | Table of Contents | Next

Reports

Fast-Forward Playback of Recent Memory Sequences in Prefrontal Cortex During Sleep

David R. Euston, Masami Tatsuno, Bruce L. McNaughton*

As previously shown in the hippocampus and other brain areas, patterns of firing-rate correlations between neurons in the rat medial prefrontal cortex during a repetitive sequence task were preserved during subsequent sleep, suggesting that waking patterns are reactivated. We found that, during sleep, reactivation of spatiotemporal patterns was coherent across the network and compressed in time by a factor of 6 to 7. Thus, when behavioral constraints are removed, the brain's intrinsic processing speed may be much faster than it is in real time. Given recent evidence implicating the medial prefrontal cortex in retrieval of long-term memories, the observed replay may play a role in the process of memory consolidation.

Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724–5115, USA.

* To whom correspondence should be addressed. E-mail: bruce{at}nsma.arizona.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Formation of Recent and Remote Memory Is Associated with Time-Dependent Formation of Dendritic Spines in the Hippocampus and Anterior Cingulate Cortex.
L. Restivo, G. Vetere, B. Bontempi, and M. Ammassari-Teule (2009)
J. Neurosci. 29, 8206-8214
   Abstract »    Full Text »    PDF »
Sleep Promotes the Neural Reorganization of Remote Emotional Memory.
V. Sterpenich, G. Albouy, A. Darsaud, C. Schmidt, G. Vandewalle, T. T. Dang Vu, M. Desseilles, C. Phillips, C. Degueldre, E. Balteau, et al. (2009)
J. Neurosci. 29, 5143-5152
   Abstract »    Full Text »    PDF »
Spontaneous Changes of Neocortical Code for Associative Memory During Consolidation.
K. Takehara-Nishiuchi and B. L. McNaughton (2008)
Science 322, 960-963
   Abstract »    Full Text »    PDF »
Sequence Reactivation in the Hippocampus Is Impaired in Aged Rats.
J. L. Gerrard, S. N. Burke, B. L. McNaughton, and C. A. Barnes (2008)
J. Neurosci. 28, 7883-7890
   Abstract »    Full Text »    PDF »
Preferential Reactivation of Motivationally Relevant Information in the Ventral Striatum.
C. S. Lansink, P. M. Goltstein, J. V. Lankelma, R. N. J. M. A. Joosten, B. L. McNaughton, and C. M. A. Pennartz (2008)
J. Neurosci. 28, 6372-6382
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)