Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain
Louis N. Manganas,1,3Xueying Zhang,1Yao Li,1Raphael D. Hazel,1,2S. David Smith,2Mark E. Wagshul,1Fritz Henn,2Helene Benveniste,1,2Petar M. Djuri,1Grigori Enikolopov,3*Mirjana Maleti-Savati1,3*
The identification of neural stem and progenitor cells (NPCs)by in vivo brain imaging could have important implications fordiagnostic, prognostic, and therapeutic purposes. We describea metabolic biomarker for the detection and quantification ofNPCs in the human brain in vivo. We used proton nuclear magneticresonance spectroscopy to identify and characterize a biomarkerin which NPCs are enriched and demonstrated its use as a referencefor monitoring neurogenesis. To detect low concentrations ofNPCs in vivo, we developed a signal processing method that enabledthe use of magnetic resonance spectroscopy for the analysisof the NPC biomarker in both the rodent brain and the hippocampusof live humans. Our findings thus open the possibility of investigatingthe role of NPCs and neurogenesis in a wide variety of humanbrain disorders.
1 SUNY Stony Brook, Stony Brook, NY 11794, USA. 2 Brookhaven National Laboratory, Upton, NY 11719, USA. 3 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
* To whom correspondence should be addressed. E-mail: enikolop{at}cshl.edu (G.E.); mmaleticsava{at}notes.cc.sunysb.edu (M.M.-S.).
The editors suggest the following Related Resources on Science sites:
In Science Magazine
TECHNICAL COMMENTS
Jeffrey C. Hoch, Mark W. Maciejewski, and Michael R. Gryk (1 August 2008) Science321 (5889), 640b.
[DOI: 10.1126/science.1153058] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Seth D. Friedman (1 August 2008) Science321 (5889), 640c.
[DOI: 10.1126/science.1153484] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Jacobus F. A. Jansen, John D. Gearhart, and Jeff W. M. Bulte (1 August 2008) Science321 (5889), 640d.
[DOI: 10.1126/science.1153997] |Abstract »|Full Text »|PDF »
TECHNICAL COMMENTS
Petar M. Djuric, Helene Benveniste, Mark E. Wagshul, Fritz Henn, Grigori Enikolopov, and Mirjana Maletic-Savatic (1 August 2008) Science321 (5889), 640e.
[DOI: 10.1126/science.1156889] |Abstract »|Full Text »|PDF »
NEWS OF THE WEEK
Greg Miller (9 November 2007) Science318 (5852), 899a.
[DOI: 10.1126/science.318.5852.899a] |Summary »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?.
A. J. Eisch, H. A. Cameron, J. M. Encinas, L. A. Meltzer, G.-L. Ming, and L. S. Overstreet-Wadiche (2008)
J. Neurosci.
28, 11785-11791
|Abstract »|Full Text »|PDF »
Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery.
M. Maletic-Savatic, L.K. Vingara, L.N. Manganas, Y. Li, S. Zhang, A. Sierra, R. Hazel, D. Smith, M.E. Wagshul, F. Henn, et al. (2008)
Cold Spring Harb Symp Quant Biol
|Abstract »|PDF »
Comment on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain".
,1
