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Science 9 November 2007:
Vol. 318. no. 5852, pp. 980 - 985
DOI: 10.1126/science.1147851
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Reports

Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain

Louis N. Manganas,1,3 Xueying Zhang,1 Yao Li,1 Raphael D. Hazel,1,2 S. David Smith,2 Mark E. Wagshul,1 Fritz Henn,2 Helene Benveniste,1,2 Petar M. Djuric,1 Grigori Enikolopov,3* Mirjana Maletic-Savatic1,3*

The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

1 SUNY Stony Brook, Stony Brook, NY 11794, USA.
2 Brookhaven National Laboratory, Upton, NY 11719, USA.
3 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

* To whom correspondence should be addressed. E-mail: enikolop{at}cshl.edu (G.E.); mmaleticsava{at}notes.cc.sunysb.edu (M.M.-S.).

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Comment on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain".
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Response to Comments on "Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain".
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