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Science 9 November 2007:
Vol. 318. no. 5852, p. 914
DOI: 10.1126/science.1143230
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Technical Comments

Comment on "A G Protein–Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid"

Christopher A. Johnston,1 Brenda R. Temple,2 Jin-Gui Chen,4 Yajun Gao,4 Etsuko N. Moriyama,5 Alan M. Jones,1,3* David P. Siderovski,1* Francis S. Willard1*

Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein–coupled receptor for abscisic acid. We argue that GCR2 is not likely to be a transmembrane protein nor a G protein–coupled receptor. Instead, GCR2 is most likely a plant homolog of bacterial lanthionine synthetases.

1 Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
2 Structural Bioinformatics Core Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
3 Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
4 Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
5 School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588–0660, USA

* To whom correspondence should be addressed. E-mail: alan_jones{at}unc.edu (A.M.J.); dsiderov{at}med.unc.edu (D.P.S.); fwillard{at}med.unc.edu (F.S.W.)

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Loss-of-Function Mutations in the Arabidopsis Heterotrimeric G-protein {alpha} Subunit Enhance the Developmental Defects of Brassinosteroid Signaling and Biosynthesis Mutants.
Y. Gao, S. Wang, T. Asami, and J.-G. Chen (2008)
Plant Cell Physiol. 49, 1013-1024
   Abstract »    Full Text »    PDF »
G{gamma}1 + G{gamma}2 != G{beta}: Heterotrimeric G Protein G{gamma}-Deficient Mutants Do Not Recapitulate All Phenotypes of G{beta}-Deficient Mutants.
Y. Trusov, W. Zhang, S. M. Assmann, and J. R. Botella (2008)
Plant Physiology 147, 636-649
   Abstract »    Full Text »    PDF »
Abscisic Acid Receptors: Multiple Signal-perception Sites.
X.-F. Wang and D.-P. Zhang (2008)
Ann. Bot. 101, 311-317
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)