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Science 9 November 2007:
Vol. 318. no. 5852, p. 914
DOI: 10.1126/science.1143230
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Technical Comments

Comment on "A G Protein–Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid"

Christopher A. Johnston,1 Brenda R. Temple,2 Jin-Gui Chen,4 Yajun Gao,4 Etsuko N. Moriyama,5 Alan M. Jones,1,3* David P. Siderovski,1* Francis S. Willard1*

Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein–coupled receptor for abscisic acid. We argue that GCR2 is not likely to be a transmembrane protein nor a G protein–coupled receptor. Instead, GCR2 is most likely a plant homolog of bacterial lanthionine synthetases.

1 Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
2 Structural Bioinformatics Core Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
3 Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
4 Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
5 School of Biological Sciences and Plant Science Initiative, University of Nebraska, Lincoln, NE 68588–0660, USA

* To whom correspondence should be addressed. E-mail: alan_jones{at}unc.edu (A.M.J.); dsiderov{at}med.unc.edu (D.P.S.); fwillard{at}med.unc.edu (F.S.W.)

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