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ReportsNetwork Analysis of Oncogenic Ras Activation in CancerTo investigate the unregulated Ras activation associated with cancer, we developed and validated a mathematical model of Ras signaling. The model-based predictions and associated experiments help explain why only one of two classes of activating Ras point mutations with in vitro transformation potential is commonly found in cancers. Model-based analysis of these mutants uncovered a systems-level process that contributes to total Ras activation in cells. This predicted behavior was supported by experimental observations. We also used the model to identify a strategy in which a drug could cause stronger inhibition on the cancerous Ras network than on the wild-type network. This system-level analysis of the oncogenic Ras network provides new insights and potential therapeutic strategies.
1 Beirne B. Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA. * To whom correspondence should be addressed. E-mail: Ravi{at}virginia.edu
The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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