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Bingsheng Chang,Yue Chen,Yingming Zhao,Richard K. Bruick*
Arginine methylation occurs on a number of proteins involvedin a variety of cellular functions. Histone tails are knownto be mono- and dimethylated on multiple arginine residues wherethey influence chromatin remodeling and gene expression. Todate, no enzyme has been shown to reverse these regulatory modifications.We demonstrate that the Jumonji domain–containing 6 protein(JMJD6) is a JmjC-containing iron- and 2-oxoglutarate–dependentdioxygenase that demethylates histone H3 at arginine 2 (H3R2)and histone H4 at arginine 3 (H4R3) in both biochemical andcell-based assays. These findings may help explain the manydevelopmental defects observed in the JMJD6–/– knockoutmice.
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9038, USA.
* To whom correspondence should be addressed. E-mail: richard.bruick{at}utsouthwestern.edu
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