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Science 19 October 2007:
Vol. 318. no. 5849, p. 393
DOI: 10.1126/science.1145164
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Technical Comments

Response to Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension"

Maurice A. Curtis,1,2* Monica Kam,1 Ulf Nannmark,3 Richard L.M. Faull,1 Peter S. Eriksson2{dagger}

In contrast to a previous study of Sanai et al., our study had the advantage of using serial sagittal sections of the human basal forebrain, combined with 5-bromo-2'-deoxyuridine labeling, rigorous magnetic resonance imaging, and polymerase chain reaction analysis. We believe these methods convincingly demonstrate the presence of a rostral migratory stream in the human brain that resembles that in other mammals.

1 Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
2 Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.
3 Institute of Biomedicine at Sahlgrenska Academy, Medicinaregatan 11, Box 432, SE 405 30 Göteborg, Sweden.

{dagger} Deceased.

* To whom correspondence should be addressed. E-mail: maurice.curtis{at}neuro.gu.se

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Science. ISSN 0036-8075 (print), 1095-9203 (online)