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Science 19 October 2007:
Vol. 318. no. 5849, p. 393
DOI: 10.1126/science.1145011
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Technical Comments

Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension"

Nader Sanai,1,3* Mitchel S. Berger,1 Jose Manuel Garcia-Verdugo,2 Arturo Alvarez-Buylla1,3

Curtis et al. (Research Articles, 2 March 2007, p. 1243) claimed discovery of a human neuronal migratory stream to the olfactory bulb along a putative lateral ventricular extension. However, high levels of proliferation reported with proliferating cell nuclear antigen were not confirmed using different markers, neuronal chain migration was not demonstrated, and no serial reconstruction shows a true ventricular extension.

1 Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143–0112, USA.
2 Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Apartado 22085, University of Valencia, 46071 Valencia, Spain.
3 Institute of Regenerative Medicine, HSW 1201A, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143–0520, USA.

* To whom correspondence should be addressed. E-mail: sanain{at}neurosurg.ucsf.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)