Response to Comment on "Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment"

doi:10.1126/science.1146519

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Science 12 October 2007:
Vol. 318. no. 5848, p. 196
DOI: 10.1126/science.1146519

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Technical Comments

Response to Comment on "Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment"

Gerald H. Jacobs¹^* and Jeremy Nathans²

Makous suggests that the novel color vision documented in knock-inmice neither requires visual system plasticity nor implies theemergence of a new dimension of sensory experience. We explainwhy we disagree.

¹ Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara, CA 93106, USA.
² Departments of Neuroscience, Ophthalmology, Molecular Biology and Genetics, and the Howard Hughes Medical Institute, Johns Hopkins Medical School, Baltimore, MD 21205, USA.

^* To whom correspondence should be addressed. E-mail: jacobs{at}psych.ucsb.edu

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TECHNICAL COMMENTS Comment on "Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment": Walter Makous (12 October 2007)
Science 318 (5848), 196b. [DOI: 10.1126/science.1146084]
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REPORTS Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment: Gerald H. Jacobs, Gary A. Williams, Hugh Cahill, and Jeremy Nathans (23 March 2007)
Science 315 (5819), 1723. [DOI: 10.1126/science.1138838]
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