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Deconstructing the Hedgehog Pathway in Development and Disease
Leni Jacob and
Lawrence Lum*
The Hedgehog (Hh) family of secreted signaling proteins is amaster regulator of cell fate determination in metazoans, contributingto both pattern formation during embryonic development and postembryonictissue homeostasis. In a universally used mode of action, gradeddistribution of Hh protein induces differential cell fate ina dose-dependent manner in cells that receive Hh. Though muchof this pathway has been elucidated from genetically based studiesin model organisms, such as Drosophila and mice, the importanceof Hh-mediated signaling in humans is clearly evident from malformationsand a broad range of cancers that arise when the pathway iscorrupted.
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
* To whom correspondence should be addressed. E-mail: lawrence.lum{at}utsouthwestern.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
INTRODUCTION TO SPECIAL ISSUE
L. Bryan Ray, Nancy R. Gough, Elizabeth M. Adler, and John F. Foley (5 October 2007) Science318 (5847), 61.
[DOI: 10.1126/science.318.5847.61] |Summary »|PDF »
In Science Signaling
DATABASE OF CELL SIGNALING
Hedgehog Signaling Pathway in Drosophila
Leni Jacob and Lawrence Lum Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_20386 |Specific Pathway »
DATABASE OF CELL SIGNALING
Hedgehog Signaling Pathway
Leni Jacob and Lawrence Lum Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_19889 |Canonical Pathway »
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