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Science 14 September 2007:
Vol. 317. no. 5844, p. 1500
DOI: 10.1126/science.1138956
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Technical Comments

Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"

Alan F. Rubin1 and Phil Green1,2*

Sjöblom et al. (Research Article, 13 October 2006, p. 268) reported many new genes with an apparent significant excess of mutations in breast and colorectal cancer. Reanalysis of their data with more appropriate statistical methods and background mutation rate assumptions reveals that few if any of these genes have significantly elevated mutation rates.

1 Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
2 Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

* To whom correspondence should be addressed. E-mail: phg{at}u.washington.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)