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Science 22 June 2007:
Vol. 316. no. 5832, p. 1698
DOI: 10.1126/science.1138579
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Technical Comments

Response to Comment on "Tequila, a Neurotrypsin Ortholog, Regulates Long-Term Memory Formation in Drosophila"

Thomas Preat,1* Jean-Luc Da Lage,2 Laurence Colleaux,3 Gérard Didelot,1{dagger} Florence Molinari,3 Paul Tchenio,4 Elodie Milhiet,4 Arnold Munnich,3 Marie-Louise Cariou2

Sonderegger and Patthy argue that the trypsin catalytic domains of Drosophila Tequila and human neurotrypsin are not linked by an orthology relationship. We present analyses based both on BLAST (basic local alignment search tool) comparisons and on phylogenetic relationships, which show that these two proteases do share an orthologous region that includes the trypsin domain.

1 Gènes et Dynamique des Systèmes de Mémoire, UMR CNRS 7637, Ecole Supérieure de Physique et de Chimie Industrielles, 10 rue Vauquelin 75005 Paris, France.
2 Evolution, Génomes et Spéciation, UPR CNRS 9034, avenue de la Terrasse 91198 Gif-sur-Yvette Cedex, France.
3 Département de Génétique et Unité de Recherche sur les Handicaps Génétiques de l'Enfant, INSERM U781, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, 75743 Paris Cedex 15, France.
4 Laboratoire Aimé Cotton, UPR CNRS 3321, Bâtiment 505, 91405 Orsay Cedex, France.

{dagger} Present address: Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland.

* To whom correspondence should be addressed. E-mail: thomas.preat{at}espci.fr

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Science. ISSN 0036-8075 (print), 1095-9203 (online)