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Science 18 May 2007:
Vol. 316. no. 5827, p. 982
DOI: 10.1126/science.1136935
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Technical Comments

Response to Comments on "A Centrosome-Independent Role for {gamma}-TuRC Proteins in the Spindle Assembly Checkpoint"

Hannah Müller, Marie-Laure Fogeron, Verena Lehmann, Hans Lehrach, Bodo M. H. Lange*

Weaver and Cleveland and Taylor et al. contend that our data on the involvement of the {gamma}-tubulin ring complex ({gamma}-TuRC) in the spindle assembly checkpoint (SAC) can be fully explained by kinetochore-derived checkpoint signaling. We maintain that (i) the interactions of {gamma}-TuRC with Cdc20 and BubR1, and (ii) the activation of SAC by {gamma}-TuRC depletion, in addition to the abrogation of kinetochore-microtubule interactions, argue for a more complex mechanism of SAC signaling.

Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany.

* To whom correspondence should be addressed. E-mail: lange_b{at}molgen.mpg.de

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Science. ISSN 0036-8075 (print), 1095-9203 (online)