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Science 18 May 2007:
Vol. 316. no. 5827, p. 982
DOI: 10.1126/science.1139523
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Technical Comments

Comment on "A Centrosome-Independent Role for {gamma}-TuRC Proteins in the Spindle Assembly Checkpoint"

Beth A. A. Weaver and Don W. Cleveland*

Müller et al. (Reports, 27 October 2006, p. 654) proposed a role for microtubule nucleation in mitotic checkpoint signaling. However, their observations of spindle defects and mitotic delay after depletion of {gamma}-tubulin ring complex ({gamma}-TuRC) components are fully consistent with activation of the established pathway of checkpoint signaling in response to incomplete or unstable interactions between kinetochores of mitotic chromosomes and spindle microtubules.

Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0670, USA.

* To whom correspondence should be addressed. E-mail: dcleveland{at}ucsd.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)