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Science 18 May 2007:
Vol. 316. no. 5827, p. 982
DOI: 10.1126/science.1139484
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Technical Comments

Comment on "A Centrosome-Independent Role for {gamma}-TuRC Proteins in the Spindle Assembly Checkpoint"

Stephen S. Taylor,1* Kevin G. Hardwick,2 Kenneth E. Sawin,2 Sue Biggins,3 Simonetta Piatti,4 Alexey Khodjakov,5 Conly L. Rieder,5 Edward D. Salmon,6 Andrea Musacchio7*

Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the {gamma}-tubulin ring complex ({gamma}-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that {gamma}-TuRC proteins play molecular roles in SAC activation. Because {gamma}-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

1 Faculty of Life Sciences, University of Manchester, Manchester, UK.
2 Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, UK.
3 Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
4 Department of Biotechnology and Bioscience, University of Milan-Bicocca, Milan, Italy.
5 Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
6 Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
7 Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

* To whom correspondence should be addressed. E-mail: stephen.taylor{at}manchester.ac.uk (S.S.T.); andrea.musacchio{at}ifom-ieo-campus.it (A.M.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)